Donor embryonic stem cells impede host epiblast specification in 8-cell stage chimeras by crowding and FGF4 signalling
Stanley E. Strawbridge, Anna Katharina Schrattel, Peter D. Humphreys, Ken A. Jones, Jérôme Artus, Anna‐Katerina Hadjantonakis, Alexander George Fletcher, Jennifer Nichols
The paper shows that donor ESCs displace host cells from the epiblast in chimeras through crowding and FGF4 signalling, with FGF4 acting after physical displacement.
bioRxiv · Nov 8, 2024 · PreprintDevelopmental Biology