Stanley E. Strawbridge

The paper models cell identity stability using a Markov framework, showing how mixing, competence, and commitment influence transition rates and proposes experiments to test these mechanisms.

This study shows Notch signalling regulates human ENS progenitor dynamics, affecting differentiation and migration, and links its disruption to intestinal aganglionosis.

The paper introduces a parametric failure-based model to quantify and compare cell-state transition kinetics across conditions, showing it captures delay, timescale, hazard form, and response fraction.

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

The paper describes a resource of clonal human pluripotent stem cell lines derived from embryos, showing intra- and inter-embryo variation and potential for modeling chromosomal mosaicism.

This study shows MLL2 stabilizes 3D chromatin loops during pluripotent cell differentiation without requiring its enzymatic activity.

The paper shows that donor ESCs displace host cells from the epiblast in chimeras through crowding and FGF4 signalling, with FGF4 acting after physical displacement.

The paper introduces insideOutside, a method to classify interior and exterior cells in embryos using spatial data, showing improved accuracy over existing methods.

The paper shows human naive epiblast cells can generate trophectoderm and trophoblast cells, unlike mouse embryonic stem cells, and identifies key regulators of this process.

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.

The paper tracks mouse embryonic stem cells during differentiation, finding symmetric divisions and variable lag periods before loss of pluripotency.