Anna‐Katerina Hadjantonakis

Axin1 and Axin2 regulate the WNT-signaling landscape to promote distinct mesoderm programs

The paper investigates how Axin1 and Axin2 regulate WNT signaling to specify distinct mesoderm lineages during gastrulation.

DNA Double Strand Breaks cause chromosome loss through sister chromatid tethering in human embryos

This study shows that DNA double-strand breaks in human embryos lead to chromosome loss through sister chromatid tethering and centromere-mediated separation.

Identification of a mesodermal progenitor for the pro-definitive angio-hematopoietic lineage

The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.

Transcription factors SP5 and SP8 drive primary cilia formation

This study identifies SP5 and SP8 as transcription factors that drive primary cilia formation through genetic and transcriptomic analyses in mouse embryos.

L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

The paper identifies L1CAM-driven planar cell polarity signaling as a mechanism promoting SOX2+ metastatic progenitors in lung adenocarcinoma.

ETV4 and ETV5 Orchestrate FGF-Mediated Lineage Specification and Epiblast Maturation during Early Mouse Development

This study shows that ETV4 and ETV5 regulate lineage specification and embryo patterning in mice by affecting primitive endoderm formation and pluripotency exit.

Donor embryonic stem cells impede host epiblast specification in 8-cell stage chimeras by crowding and FGF4 signalling

The paper shows that donor ESCs displace host cells from the epiblast in chimeras through crowding and FGF4 signalling, with FGF4 acting after physical displacement.

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

This study identifies OTX2 as a critical regulator of definitive endoderm specification and gut patterning through chromatin remodeling and signaling pathway regulation.

The covariance environment defines cellular niches for spatial inference

This paper introduces COVET and ENVI to model spatial niches and improve gene expression imputation and spatial context inference from single-cell data.

Amino acid intake strategies define pluripotent cell states

This study shows that mouse embryonic stem cells (ESCs) can proliferate without essential amino acids by taking up and digesting exogenous protein, mimicking pre-implantation embryos.

Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression

Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition

RNA polymerase II and PARP1 shape enhancer-promoter contacts

This study investigates enhancer-promoter contact architecture and communication, finding that RNA polymerase II and PARP1 activity stabilize these contacts.

A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT

The paper shows that epiblast cells ingress during mouse gastrulation through a ratchet-like apical constriction driven by asynchronous shrinkage of apical junctions.

Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities

The paper uses single-cell RNA and ATAC-seq to study bidirectional reprogramming between embryonic states, revealing differences in lineage plasticity.

ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions

This study identifies ZFP281 as a coordinator of DNMT3A/3B and TET1 to regulate DNA methylation and gene expression during pluripotent stem cell state transitions.

3D genome topologies distinguish pluripotent epiblast and primitive endoderm cells in the mouse blastocyst

The paper examines 3D genome structures in mouse blastocyst cells to identify lineage-specific chromatin organization differences between epiblast and primitive endoderm cells.

SARS-CoV-2 Can Infect Human Embryos

This study shows SARS-CoV-2 can infect human embryos, specifically trophectoderm cells in blastocysts, with potential implications for reproductive health.

RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription

The paper shows that RNA Pol II pausing is essential for proper pluripotency transitions in mouse embryos by maintaining balance between gene expression states.

Rapid and efficient adaptation of the dTAG system in mammalian development reveals stage specific requirements of NELF

The paper validates the dTAG system for in vivo protein degradation during mammalian development, showing its safety, efficiency, and stage-specific effects on NELFB function.

Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis

This paper uses spatial transcriptomics to study mouse organogenesis, revealing spatial gene expression patterns and cell fate decisions not captured by single-cell RNA sequencing.

Quantitative analysis of signaling responses during mouse primordial germ cell specification

The paper quantifies signaling responses in mouse primordial germ cells and their niche, showing distinct BMP and MAPK responses compared to somatic cells, but comparable WNT responses, and finds BMP signaling is not cell-autonomously required for PGC-like differentiation.

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryos

This study shows that Rreb1 is essential for mouse embryonic development, regulating epithelial architecture and invasiveness during gastrulation.

Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

The paper develops a mathematical model showing growth factor signaling ensures robustness in mammalian embryo development by coupling lineage size and cell fate choice.

Transitions in cell potency during early mouse development are driven by Notch

This study identifies Notch's role in driving cell potency transitions during early mouse development, revealing novel targets and interactions with Hippo signaling.

Charting the emergent organotypic landscape of the mammalian gut endoderm at single-cell resolution

The paper maps the developmental trajectories of endoderm cells in the mouse embryo to reveal lineage relationships and spatial organization during gut formation.

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized fates and patterning

The paper develops a mouse pluripotent stem cell micropattern system to study regionalized fate specification and patterning, revealing how signals direct distinct identities and spatial organization.