5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA
Matthew B. Pomrenze, Sam Vaillancourt, Juliana S. Salgado, Kendall B. Raymond, Pierre Llorach, Hiroaki Sacai, Daniel Ryskamp Rijsketic, Tuuli M Hietamies, Gavin C. Touponse, Daniel F. Cardozo Pinto, Zahra Rastegar, Austen B. Casey, Neir Eshel, Robert C. Malenka, Boris Dov Heifets
This paper investigates how 5-HT2C receptors in the nucleus accumbens modulate MDMA's rewarding effects and prosocial behaviors through interactions with serotonin and dopamine release.
Molecular Psychiatry · Jul 24, 2025Peer-reviewedNeuroscience