Boris Dov Heifets

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

This paper investigates how 5-HT2C receptors in the nucleus accumbens modulate MDMA's rewarding effects and prosocial behaviors through interactions with serotonin and dopamine release.

This study shows psilocybin does not have analgesic effects in acute or chronic mouse pain models across various pain types and doses.

This study investigates psilocybin's effects on mouse behavior through a multi-laboratory collaboration, finding robust acute effects but inconsistent persistent effects.

This study identifies a brain-wide neural ensemble involved in anesthesia-induced unconsciousness, with the lateral parabrachial nucleus as a central hub.

This study maps the brain-wide network activated by NAc DBS in mice and finds similar connectivity patterns in humans, suggesting conserved mechanisms across species.

The paper identifies opioid receptor-expressing neurons in the central amygdala as mediators of ketamine's behavioral effects in mice, showing they are not direct targets of ketamine.

This study identifies an immune signature predicting postoperative cognitive decline using single-cell and plasma proteomic data from elderly patients.

This study examines how psilocybin and environment affect brain-wide immediate early gene expression in mice using c-Fos immunofluorescence and light sheet microscopy.

This paper presents interim results from a study examining how ketamine affects dissociative and affective states and brain connectivity in human subjects.

This study identifies distinct neural mechanisms for MDMA's prosocial effects and rewarding properties in mice, showing serotonin transporter and dopaminergic signaling play separate roles.