Asynchronous Transitions from Hepatoblastoma to Carcinoma in High-Risk Pediatric Tumors
Xinjian Yu, Stephen Frederick Sarabia, Martin Urbicain, Sonal Somvanshi, Roma H. Patel, Priyanka Rao, Tuan M. Tran, Yen-Ping Yeh, Keng-Shih Chang, Yi-Tzu Lo, Jessica L. Epps, Kathleen A. Scorsone, Hua‐Sheng Chiu, Emporia Faith Hollingsworth, Cintia Perez, , Pavel Sumazin
The paper characterizes hepatoblastoma with carcinoma features (HBCs) using multi-omics data, revealing their heterogeneous composition, worse outcomes, and origin from arrested HB cells due to WNT signaling.
Journal of Hepatology · Feb 28, 2026Peer-reviewedGenomics