Conserved Metastatic Cell States and Spatial Immune Microenvironment Remodeling Define Pancreatic Cancer Liver Metastases
Ayushi Mandloi, Christina R. Larson, Tuan M. Tran, Sudharonjon Roy, Ateeq Muhammed Khaliq, Yu-Hua Dean Fang, Jace Baines, Richard Laube, Meet Patel, Christopher A. Risley, Robert S. Welner, Satwik Acharyya, Ashiq Masood, Julienne L. Carstens
The paper identifies conserved transcriptional programs in pancreatic cancer liver metastases and shows how they interact with spatial immune microenvironments to drive metastatic progression.
bioRxiv · Sep 20, 2026 · PreprintCancer Biology