Hua‐Sheng Chiu

Asynchronous Transitions from Hepatoblastoma to Carcinoma in High-Risk Pediatric Tumors

The paper characterizes hepatoblastoma with carcinoma features (HBCs) using multi-omics data, revealing their heterogeneous composition, worse outcomes, and origin from arrested HB cells due to WNT signaling.

Characterization of Chemoresistant Cell Populations Improves Risk Stratification and Therapy Prediction in Pediatric AML

The paper identifies chemoresistant cell populations in pediatric AML that improve risk prediction and reveal therapeutic targets for high-risk patients.

Coordinated regulation by lncRNAs results in tight lncRNA-target couplings

The paper identifies lncRNAs that coordinately regulate both transcription and post-transcriptional processing of their targets, showing tight coupling between lncRNA and target abundance, with implications for cancer gene regulation.

Effective methods for bulk RNA-Seq deconvolution using scnRNA-Seq transcriptomes

The paper evaluates deconvolution methods for bulk RNA-Seq using scnRNA-Seq data, identifies biases, and introduces SQUID, a method that outperforms others in predicting cell mixtures and identifying cancer subclones.

The RNA Atlas, a single nucleotide resolution map of the human transcriptome

The paper presents a comprehensive human transcriptome atlas with single-nucleotide resolution, identifying thousands of novel RNA species and regulatory interactions.

LIN28 selectively modulates a subclass of let-7 microRNAs

The paper identifies a GAU motif recognized by LIN28's CSD domain, which enhances let-7 microRNA suppression in Class I precursors, contributing to development and cancer.