Repurposing the quinoline antibiotic nitroxoline to treat infections caused by the brain-eating amoeba Balamuthia mandrillaris
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi
This paper identifies nitroxoline as a potent inhibitor of Balamuthia mandrillaris, showing greater efficacy than current treatments for granulomatous amoebic encephalitis.
bioRxiv · Jun 6, 2018 · PreprintPharmacology & Toxicology