Nuclear NFκB Activity Balances Purine Metabolism in Cellular Senescence
Sho Tabata, Keita Matsuda, Kenshiro Nagai, Yoshihiro Izumi, Masatomo Takahashi, Yasutaka Motomura, Ayaka Ichikawa Nagasato, Shuichi Shimma, Kazuyo Moro, Takeshi Bamba, Mariko Okada
This study shows that sustained NFκB activity promotes cellular senescence by altering purine metabolism and epigenetic regulation through IκB and A20 dysfunction.
bioRxiv · Apr 18, 2023 · PreprintSystems Biology