Author

Ayaka Ichikawa Nagasato

Institute for Protein Research, The University of OsakaORCID 0000-0003-0791-8933Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Mariko OkadaiD· 2 shared Kazuhiro AokiiD· 1 shared Kazuyo MoroiD· 1 shared Keita Matsuda· 1 shared Ken MurakamiiD· 1 shared Kenshiro Nagai· 1 shared Masatomo TakahashiiD· 1 shared Sho Tabata· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Mariko OkadaORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Biological ChemistryPeer-reviewedOct 28, 2025

ErbB2/HER2 governs CDK4 inhibitor sensitivity and timing and irreversibility of G1/S transition by altering c-Myc and cyclin D function

Ayaka Ichikawa Nagasato, Ken Murakami, Kazuhiro Aoki, Mariko Okada

This study shows how ErbB2 levels affect CDK4 inhibitor sensitivity and the timing of G1/S transition by altering c-Myc and cyclin D function in breast cancer cells.

2 citations

humanbulk RNA-seq

Systems BiologybioRxivPreprintApr 18, 2023

Nuclear NFκB Activity Balances Purine Metabolism in Cellular Senescence

Sho Tabata, Keita Matsuda, Kenshiro Nagai…·Mariko Okada

This study shows that sustained NFκB activity promotes cellular senescence by altering purine metabolism and epigenetic regulation through IκB and A20 dysfunction.

1 citation

mousestatistical model