Ectopic overproduction of cell wall glucan through membrane perturbation by an antifungal peptide theonellamide A in fission yeast
Kensuke Nakao, Vanessa S. D. Carvalho, Akifumi Suganaga, Masako Osumi, Masato Tokukura, Hideaki Kakeya, Akihisa Matsuyama, Yoko Yashiroda, Shigeki Matsunaga, Juan Carlos G. Cortés, Minoru Yoshida, Juan Carlos Ribas, Shinichi Nishimura
This study shows that the antifungal peptide TNM-A causes ectopic overproduction of cell wall glucan in fission yeast by altering Cdc42 activation and glucan synthase localization.
iScience · Oct 1, 2026Peer-reviewedCell Biology