Minoru Yoshida

Ectopic overproduction of cell wall glucan through membrane perturbation by an antifungal peptide theonellamide A in fission yeast

This study shows that the antifungal peptide TNM-A causes ectopic overproduction of cell wall glucan in fission yeast by altering Cdc42 activation and glucan synthase localization.

Glutathione acts as an exometabolite that rescues functionally distinct genetic mutations in fission yeast

This study identifies glutathione as an exometabolite that rescues growth and morphology defects in fission yeast mutants through both nutritional and non-nutritional mechanisms.

CGK733 binds to adenine nucleotide translocator 2 and modulates mitochondrial function and protein translation

This study identifies ANT2 as the target of CGK733, showing it modulates mitochondrial function and protein translation by altering ATP export and metabolic pathways.

Catalytic regulation of CoA transferase by an NAD+-sensing accessory protein and protein acetylation

This study identifies a dual regulatory mechanism for a CoA transferase in Thermus thermophilus, controlled by NAD+-sensing and acetylation, which fine-tunes β-oxidation flux based on cellular metabolic states.

Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast

This study shows that pentadecanoic acid causes lipotoxicity in fission yeast by forming giant ER sheets, disrupting cell division.

Synchronization between chloroplastic and cytosolic protein synthesis for photosynthesis complex assembly

The paper investigates the coordination of chloroplast and cytoplasmic protein synthesis during light/dark transitions in plants, revealing translational control in chloroplasts and mRNA abundance control in the cytoplasm.

Pateamine A mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs

This paper identifies pateamine A as a small-molecule compound that selectively represses mRNA translation by anchoring eIF4A and DDX3 to GNG motifs.

UBL3 interaction with α-synuclein is downregulated by silencing MGST3

The paper identifies MGST3 as a key regulator that downregulates the UBL3-α-syn interaction, with oxidative stress also contributing to this effect.

UBL3 Interacts with Alpha-synuclein in Cells and the Interaction is Downregulated by the EGFR Pathway Inhibitor Osimertinib

This study shows UBL3 interacts with alpha-synuclein in cells and this interaction is reduced by osimertinib treatment.

Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

The paper shows splicing modulators cause translational repression by inducing condensate-prone intron-derived proteins that inhibit mTORC1 and trigger proteotoxic stress.

Improving prediction of compound function from chemical structure using chemical-genetic networks

The paper benchmarks structure descriptors and similarity coefficients using chemical-genetic interaction data to improve compound function prediction.

Genome-wide survey of ribosome collision

The paper identifies genome-wide ribosome collision sites in humans and zebrafish, revealing their sequence motifs and functional roles in protein synthesis.

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interaction networks

The paper develops CG-TARGET to predict compound biological processes by integrating chemical-genetic and genetic interaction networks, showing improved accuracy and FDR control.

MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action

The paper introduces MOSAIC, a database and web resource for chemical-genetic interaction data, enabling mode-of-action prediction and discovery of compound effects in yeast.

Functional Annotation of Chemical Libraries across Diverse Biological Processes

This study develops a yeast-based chemical-genetic screening system to annotate compound functionality across biological processes and identifies compounds with dual modes of action.