Metastable Dimeric Intermediate Drives Native-like Spidroin Fibrillogenesis, while Dehydration Promotes Cross-β Transition
Haruya Kajimoto, Kento Yonezawa, Kok Sim Chan, Kiichi Hayashi, Yusuke Okamoto, Rakuri Aiba, Yuki Nakatani, Kenta Kimura, Minami Bessho, Yoichi Yamazaki, Sachiko Toma-Fukai, Takayuki Uchihashi, Takehiro K. Sato, Hironari Kamikubo
This paper identifies a metastable dimeric intermediate essential for forming native-like spidroin fibrils, but shows dehydration causes irreversible transition to amyloid-like cross-β structures.
bioRxiv · Sep 14, 2026 · PreprintBiophysics