Sachiko Toma-Fukai

This paper identifies a metastable dimeric intermediate essential for forming native-like spidroin fibrils, but shows dehydration causes irreversible transition to amyloid-like cross-β structures.

The paper determines the crystal structure of the OPEN-form adenylate kinase/monobody OP-4 complex and identifies key residues critical for binding.

This study identifies microtubule and dynein inhibitors that block ZFTA-RELA nuclear localization and NF-κB activation in ependymoma cells.

The paper determines the Cryo-EM structure of PPARγ in complex with Transportin-1, revealing a non-canonical NLS recognition mechanism.

This paper demonstrates the use of intensity-based hierarchical clustering to detect structural polymorphs in diffraction datasets from multiple crystals.