Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma
Xin Liu, Zelong Liu, Chengzhan Zhu, Tatsuya Kobayashi, Pin‐Ji Lei, Yue Shi, Dandan Yuan, Jianguo Wang, Min Li, Aya Matsui, Kassiana Mafra, Tomofumi Ando, Ken Kojo, Rieke Schleinhege, Kento Miyazaki, , Dan Gabriel Duda
This study shows that B-cell depletion or TIM-1 targeting enhances immunotherapy efficacy in HCC by reducing B-cell-mediated immunosuppression and improving antigen presentation.
Nature Communications · Dec 8, 2025Peer-reviewedCancer Biology