Lloyd Bod

HARP integrates PBMC data from multiple studies to create a reference atlas with consensus annotations and identifies age, sex, and disease-related cellular modules.

The paper maps chemokine landscapes in solid tumors using spatial transcriptomics, identifying conserved and tumor-specific patterns and revealing perivascular CCR7 dendritic cells as key sources of lymphocyte-attracting chemokines.

This study shows that B-cell depletion or TIM-1 targeting enhances immunotherapy efficacy in HCC by reducing B-cell-mediated immunosuppression and improving antigen presentation.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

The paper introduces Compass, an algorithm that uses single-cell RNA-Seq and flux balance analysis to characterize metabolic states in Th17 cells, revealing a metabolic switch and novel anti-inflammatory regulators.