Impaired glycolysis in aged endothelial cells is associated with reduced neovascularisation upon tissue ischemia
Kevin Kiesworo, Thomas Agius, Arnaud Lyon, Michael Robert MacArthur, Jing Zhang, Sébastien Déglise, James F. Markmann, Korkut Uygun, Heidi Yeh, Katrien De Bock, Sarah Jayne Mitchell, Alejandro Ocampo, Florent Allagnat, Alban Longchamp
This study identifies impaired glycolysis in aged endothelial cells as a factor limiting neovascularization during tissue ischemia.
bioRxiv · Jan 26, 2024 · PreprintMolecular Biology