Sarah Jayne Mitchell

Pharmacologic AMPK Activation Extends Lifespan in C. elegans and Improves Aspects of Healthspan in Mice

This study shows that pharmacologic AMPK activation with MK-8722 extends lifespan in C. elegans and improves metabolic health in aged mice.

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

Mapping the mammalian dark metabolome by in vivo isotope tracing

The paper uses in vivo isotope tracing and AI to identify biosynthetic origins of unknown metabolites, revealing new metabolic pathways and age-related changes.

ATG-18 drives longevity in an HLH-30-dependent manner

This study shows that ATG-18 overexpression extends C. elegans lifespan and improves stress resilience through the HLH-30 transcription factor, while also revealing a temporal-specific effect on heat stress survival.

Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation

SAAR improves exercise capacity in mice by enhancing fat oxidation and substrate availability through VEGF signaling and CD36-dependent fatty acid transport.

Lack of consistent effect of dietary fiber on immune checkpoint blockade efficacy across diverse murine tumor models

This study investigates the effect of dietary fiber on immune checkpoint blockade efficacy in murine tumor models and finds inconsistent results across different models.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

Long-term fasting remodels gut microbial metabolism and host metabolism

This study shows that long-term fasting changes gut microbial composition and function, as well as the serum metabolome, with significant shifts in microbial species and metabolite levels.

Impaired glycolysis in aged endothelial cells is associated with reduced neovascularisation upon tissue ischemia

This study identifies impaired glycolysis in aged endothelial cells as a factor limiting neovascularization during tissue ischemia.

Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice

TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions

The paper introduces TIME-Seq, a low-cost method for epigenetic age prediction, and validates it on mouse and human samples, showing improved scalability and accuracy.

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.