Alejandro Ocampo

This study evaluates 16 lifespan-extending molecules in C. elegans, confirming some effects, identifying synergies, and finding conserved effects in Drosophila.

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

This study shows that partial reprogramming of dentate gyrus neurons in mice improves memory and learning in aged animals.

This study induces in vivo reprogramming in C. elegans and finds it leads to heterogeneous effects on lifespan depending on developmental stage.

This study compares mouse strains for in vivo reprogramming to develop safer strategies and create a comprehensive atlas of reprogrammable strains.

This study identifies impaired glycolysis in aged endothelial cells as a factor limiting neovascularization during tissue ischemia.

The paper compares DNA methylation age in four premature aging mouse models, finding ERCC1 mice show the most significant increase in epigenetic age.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.

This paper develops an aging clock using chromatin accessibility data from PBMCs and shows it correlates with transcriptional changes during aging.

The paper compares gene expression in a mouse model of status epilepticus to human temporal lobe epilepsy tissue, finding high concordance in gene dysregulation and shared molecular features.