Author
Lawrence Berkeley National Laboratory
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Brandon J. Mannion, Stella Tran, Ingrid Plajzer-Frick…·Len A. Pennacchio
The paper identifies hidden enhancers in mouse embryos that are not detected by conventional chromatin profiling methods, highlighting a significant gap in enhancer discovery.
Michael Kosicki, Boyang Zhang, Vivian C. Hecht…·Len A. Pennacchio
The paper maps the mutagenic sensitivity of human enhancers in vivo by systematically mutating enhancer sequences and using predictive modeling to identify critical nucleotides.
Michael Kosicki, Dianne Laboy Cintrón, Nicholas F. Page…·Nadav Ahituv
The paper combines massively parallel reporter assays and mouse transgenic assays to study the functional impact of non-coding variants on neuronal enhancer activity, finding strong correlations and additional pleiotropic effects.
Sudha Sunil Rajderkar, Kitt D. Paraiso, Maria Luisa Amaral…·Axel Visel
The paper identifies 14,000 human craniofacial enhancers across developmental stages and shows 56% are conserved in mice, providing cell type- and stage-specific activity profiles.
Sudha Sunil Rajderkar, Iros Barozzi, Yiwen Zhu…·Len A. Pennacchio
This study shows that deleting TAD boundaries in mice often causes molecular or developmental phenotypes, highlighting their importance for genome function.