Iros Barozzi

This study shows JAK1/2 inhibition reduces pathogenic immune responses and restores tissue integrity in chronic skin inflammation by shifting immunity toward IL-17 responses.

This study uses PhIP-Seq to analyze antibody repertoires in CRC patients and controls, finding specific microbial antigens associated with CRC and non-cancer stages.

This study characterizes the electrophysiological maturation of human cardioids over three weeks, showing progressive changes in membrane potential, action potential amplitude, and duration.

The paper profiles myeloid cells in breast cancer primary tumors and metastases to show how tumor heterogeneity drives shifts in myeloid cell phenotypes from anti- to pro-metastatic.

The paper identifies essential cardiac enhancer modules and regulatory mechanisms governing heart development, revealing resilience in cis-regulatory architectures and the role of Hand2 upstream regulatory intervals.

The paper examines 3D enhancer-promoter interactions during mammalian development, finding that most enhancers bypass neighboring genes and show tissue-specific conformations with increased interactions upon activation.

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

The paper identifies 14,000 human craniofacial enhancers across developmental stages and shows 56% are conserved in mice, providing cell type- and stage-specific activity profiles.

The paper identifies widespread epigenomic changes in idiopathic dilated cardiomyopathy, showing a shift toward fetal-like enhancer states and providing a data resource for further study.

The paper identifies a transcription factor network and enhancers involved in cortical regional patterning using mouse embryonic data.

The paper identifies SMAD4 target genes and their role in integrating BMP and SHH signaling during early limb bud development, revealing opposing regulatory effects on anterior and posterior gene expression.

This study shows that deleting TAD boundaries in mice often causes molecular or developmental phenotypes, highlighting their importance for genome function.

This study identifies a gene desert critical for Shox2 regulation and embryonic survival through enhancer networks in mouse development.

This paper develops a cross-organism framework for enhancer prediction using Drosophila STARR-seq data and supervised machine learning, validated in mouse and human with 153 enhancers.

The paper systematically maps chromatin state landscapes during mouse development by profiling histone modifications across 72 tissue-stages, identifying dynamic enhancers and transcriptional regulators.

The paper develops a framework to analyze nucleosome remodeling in response to stimuli and finds that remodeling preferentially affects poorly positioned nucleosomes at enhancers.

This study investigates how TPO signaling rapidly remodels the epigenome in HSPCs by altering cis-regulatory activity and chromatin architecture.