Dianne Laboy Cintrón

Large-scale discovery of neural enhancers for cis-regulation therapies

The paper identifies active human neural enhancers and CRISPRa gRNAs that upregulate NDD risk genes, providing a resource for cis-regulatory therapy development.

Active learnings impact on student course performance in STEM varies by type and intensity

This study updates a meta-analysis showing active learning improves STEM student exam scores by 0.519 standard deviations, with higher intensity and varied types showing more effectiveness.

Massively parallel reporter assays and mouse transgenic assays provide complementary information about neuronal enhancer activity

The paper combines massively parallel reporter assays and mouse transgenic assays to study the functional impact of non-coding variants on neuronal enhancer activity, finding strong correlations and additional pleiotropic effects.

Integrative single-cell characterization of hypothalamus sex-differential and obesity-associated genes and regulatory elements

The paper integrates single-cell RNA and ATAC-seq data from mouse and human hypothalamus to identify sex-specific genes and obesity-associated regulatory elements.