Efficacy profiling of structurally diverse cannabinoid receptor ligands across transducer-coupling assays
Soo Jung Oh, Christopher Lucaj, Kiera Truong, 郭瑞茹, Hayato Umaoka, Christos Iliopoulos‐Tsoutsouvas, Maria Gerasi, Markos‐Orestis Georgiadis, Lipin Ji, Spyros P. Nikas, Alexandros Makriyannis, Hideaki Yano
The paper profiles the efficacy of 22 cannabinoid ligands at CB1 and CB2 receptors using BRET assays, finding consistent trends in agonist efficacy and antagonist effects.
bioRxiv · Oct 2, 2026 · PreprintPharmacology & Toxicology