A water-pinning hotspot drives templated tau aggregation
Chung-Ta Han, Karen Tsay, Samuel Lobo, Saeed Najafi, Kieran Monahan, Erica Hong, M. Scott Shell, Joan‐Emma Shea, Songi Han
In a minimal tau fibril model, residue 300/301 binds incoming peptide first and carries the most release-prone hydration water. Spin-labelling site 300 impairs locking and suppresses seeded growth.
bioRxiv · Sep 25, 2026 · PreprintBiophysics✦ In-depth digest