BiophysicsbioRxivPreprint
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A water-pinning hotspot drives templated tau aggregation
Chung-Ta Han, Karen Tsay, Samuel Lobo…·Songi Han
In a minimal tau fibril model, residue 300/301 binds incoming peptide first and carries the most release-prone hydration water. Spin-labelling site 300 impairs locking and suppresses seeded growth.
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