Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients
Alastair Smith, Nicholas Denny, Catherine Chahrour, Kim Sharp, Marta Arachi, Ana M. Dopico-Fernandez, Natalina Elliott, Joe R. Harman, Thomas Jackson, Huimin Geng, Owen Patrick Smith, Jonathan Bond, Irene A.G. Roberts, Ronald W. Stam, Nicholas T. Crump, , Thomas A. Milne
This study identifies enhancer heterogeneity as a driver of transcriptional differences in KMT2A::AFF1 ALL patients, revealing patient-specific enhancer activity at oncogenes.
Blood · Jul 29, 2025Peer-reviewedCancer Biology