Author

Owen Patrick Smith

University College DublinORCID 0000-0002-2922-2067Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

Anindita RoyiD· 2 shared Christina HalseyiD· 2 shared Irene A.G. RobertsiD· 2 shared Jonathan BondiD· 2 shared Natalina ElliottiD· 2 shared Thomas A. MilneiD· 2 shared Thomas JacksoniD· 2 shared Alasdair DuguidiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Anindita RoyORCID

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3 papers

Recent·Most cited

Cancer BiologyBloodPeer-reviewedJul 29, 2025

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients

Alastair Smith, Nicholas Denny, Catherine Chahrour…·Thomas A. Milne

This study identifies enhancer heterogeneity as a driver of transcriptional differences in KMT2A::AFF1 ALL patients, revealing patient-specific enhancer activity at oncogenes.

8 citationstop 2%

humanscRNA-seq

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Cancer BiologybioRxivPreprintJan 22, 2025

Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease

Hongwei Ren, Natalina Elliott, Bryan Lye…·Anastasios Karadimitris

This paper develops bi-specific CAR-iNKT cells targeting CD19 and CD133 for KMT2A-rearranged leukemia, showing superior efficacy over CAR-T in eradicating leptomeningeal disease and inducing remission.

2 citations

mouseproteomics

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Cancer BiologybioRxivPreprintDec 3, 2024

Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche.

Alasdair Duguid, Camille Malouf, Leslie Nitsche…·Katrin Ottersbach

This study identifies miR-93 as a key regulator of KMT2A-rearranged B-ALL survival in the CNS niche through transcriptomic and immune profiling in a murine model.

DOI 10.1101/2024.12.03.626602

mousebulk RNA-seq

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