Author
University of OxfordORCID 0000-0003-3668-1859Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Rebecca E. Ling, Alia M. N. Welsh, Lucy Hamer…·Anindita Roy
This study identifies LIN28B as essential for fetal B-lymphopoiesis and KMT2A::AFF1 infant leukemia initiation, showing its role in promoting proliferation and leukemogenesis.
Alastair Smith, Nicholas Denny, Catherine Chahrour…·Thomas A. Milne
This study identifies enhancer heterogeneity as a driver of transcriptional differences in KMT2A::AFF1 ALL patients, revealing patient-specific enhancer activity at oncogenes.
I‐Jun Lau, Joe R. Harman, Alastair Smith…·Thomas A. Milne
This study shows that MYB activity sustains enhancer-promoter interactions and transcription by maintaining enhancer function in leukemia.
Nicholas T. Crump, Alastair Smith, Laura Godfrey…·Thomas A. Milne
This study identifies PAF1 and FACT as essential for enhancer activity in MLL-AF4-driven leukemia by maintaining histone acetylation and enhancer-promoter interactions.
Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar…·Marella F. T. R. De Bruijn
The paper examines how dynamic chromatin boundaries around the Runx1 gene influence its expression during hematopoietic development in mice.
Joe R. Harman, Ross Thorne, Max Jamilly…·Thomas A. Milne
The paper constructs a gene regulatory network for MLL-AF4 to reveal an indirect repression of CASP9 via RUNX1 as a mechanism of apoptosis resistance.
Laura Godfrey, Nicholas T. Crump, Ross Thorne…·Thomas A. Milne
The paper identifies a distinct class of enhancers in leukemia cells that depend on H3K79 methylation and shows that DOT1L inhibition disrupts their function.