Targeting p16INK4a reverses alveolar epithelial cell dysfunction and induces lung regeneration in emphysema
Bruno Ribeiro Baptista, Marylène Toigo, Grégoire Justeau, Perla Abou Atmeh, Thalles de Freitas Castro, M. Zysman, Charlotte Thibaut de Ménonville, Étienne Audureau, Klara Schnyder, Huijuan Wang, Yan Hu, Melanie Koenigshoff, Sophie Lanone, F. Chabot, Elodie Zana‐Taïeb, , Laurent Boyer
This study shows that deleting p16INK4a or targeting p16+ cells reverses alveolar epithelial dysfunction and promotes lung regeneration in emphysema.
bioRxiv · Sep 5, 2025 · PreprintCell Biology