M. Zysman

This study shows that deleting p16INK4a or targeting p16+ cells reverses alveolar epithelial dysfunction and promotes lung regeneration in emphysema.

The paper develops a tunable 3D-alveolosphere model from human primary AEC2 cells to study emphysema, showing key native alveolar features and pathophysiological responses to cigarette smoke extract.

The paper introduces a bronchioid model using human bronchial stem cells in an alginate scaffold to mimic distal airway structure and function, showing ciliary activity and pathophysiological features.