Multi-trait Analysis of GWAS (MTAG) of Substance Use Traits Identifies Novel Genetic Loci and Phenomic Associations
Heng Xu, Sylvanus Toikumo, Richard C. Crist, Klaudia Glogowska, Joseph D. Deak, Joel E. Gelernter, Emma C. Johnson, Henry R. Kranzler, Rachel L. Kember
This paper applies MTAG to GWAS of substance use traits, identifying novel genetic loci and showing improved polygenic risk scores for four disorders.
medRxiv · Jul 6, 2022 · PreprintGenetic & Genomic Medicine