Heng Xu

Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample

This study identifies genetic loci associated with alcohol use disorder and consumption, finding distinct genetic architectures and variants with direct effects on AUD.

Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.

Phenome-wide association analysis of substance use disorders in a deeply phenotyped sample

The paper uses polygenic risk scores and phenome-wide association studies to examine pleiotropy in substance use disorders using a deeply phenotyped sample.

Polygenic Risk for Substance-Related Traits Predicts Substance Use Onset and Progression: Sex and Population Group Differences

This study shows polygenic risk scores for substance use disorders predict substance use milestones and progression, with differences by sex and population group.

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

This study performs a cross-ancestry meta-analysis of opioid use disorder, identifying 14 loci, including 12 novel ones, and finding significant genetic correlations with psychiatric and neurological traits.

Multi-trait Analysis of GWAS (MTAG) of Substance Use Traits Identifies Novel Genetic Loci and Phenomic Associations

This paper applies MTAG to GWAS of substance use traits, identifying novel genetic loci and showing improved polygenic risk scores for four disorders.