Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice
Anna Henzi, Assunta Senatore, Asvin KK Lakkaraju, Claudia Scheckel, Jonas Mühle, Regina Reimann, Silvia Sorce, Gebhard F. X. Schertler, Klaus Viktor Toyka, Adriano Aguzzi
This study tests a dimeric prion protein ligand as a therapy for peripheral demyelination but finds it fails to rescue myelinopathy in PrP-deficient mice.
PLoS ONE · Nov 12, 2020Peer-reviewedNeuroscience