Author

Anna Henzi

University of ZurichORCID 0000-0002-5712-7059Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriano AguzziiD· 3 shared Assunta SenatoreiD· 2 shared Asvin KK LakkarajuiD· 2 shared Regina ReimanniD· 2 shared Caihong ZhuiD· 1 shared Claudia ScheckeliD· 1 shared Federica Mazzola· 1 shared Gebhard F. X. SchertleriD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Adriano AguzziORCID

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3 papers

Recent·Most cited

Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedAug 1, 2022

A conformational switch controlling the toxicity of the prion protein

Karl Frontzek, Marco Bardelli, Assunta Senatore…·Adriano Aguzzi

This study identifies an H-latch conformational switch in PrPC that drives prion toxicity and shows that disrupting this switch can protect against prion-related neurodegeneration.

35 citations

mouseprotein structure

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NeurosciencePLoS ONEPeer-reviewedJan 22, 2021

The prion protein is not required for peripheral nerve repair after crush injury

Anna Henzi, Adriano Aguzzi

This study shows that the prion protein is not required for sciatic nerve regeneration after crush injury in mice.

5 citations

mouseexperimental assay

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NeurosciencePLoS ONEPeer-reviewedNov 12, 2020

Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice

Anna Henzi, Assunta Senatore, Asvin KK Lakkaraju…·Adriano Aguzzi

This study tests a dimeric prion protein ligand as a therapy for peripheral demyelination but finds it fails to rescue myelinopathy in PrP-deficient mice.

13 citations

mousebulk RNA-seq

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