Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates
Elizabeth J. Fay, Kolya Isterabadi, Charles M Rezanka, Jessica Le, Matthew D. Daugherty
The paper analyzes the evolutionary and functional roles of RIPK3 and its RHIM domain across vertebrates, finding that RHIM diversity tunes NF-κB activation while preserving cell death function.
eLife · May 28, 2025Peer-reviewedEvolutionary Biology