Matthew D. Daugherty

Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

The paper presents Cryo-EM structures of the CRL2-ZYG11B complex with substrates, revealing how ZYG11B recognizes and ubiquitinates Gly/N-degrons to activate the NLRP1 inflammasome.

CLCC1 promotes membrane fusion during herpesvirus nuclear egress.

The paper identifies CLCC1 as a host factor essential for herpesvirus nuclear egress fusion, showing its role in membrane fusion and nuclear envelope morphogenesis.

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

The paper analyzes the evolutionary and functional roles of RIPK3 and its RHIM domain across vertebrates, finding that RHIM diversity tunes NF-κB activation while preserving cell death function.

Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex

The paper shows that short 5' UTRs in viral mRNAs are recognized by the IFIT2-IFIT3 complex, leading to translation inhibition and antiviral activity.

Acquired stress resilience through bacteria-to-nematode horizontal gene transfer

The paper identifies a nematode gene acquired via horizontal gene transfer from bacteria that enhances stress resilience by enabling L-rhamnose biosynthesis for cuticle integrity.

Co-opted Genes of Algal Origin Protect C. elegans against Cyanogenic Toxins

This study identifies a genetic pathway in C. elegans that detoxifies amygdalin by co-opting algal genes acquired via horizontal gene transfer.

Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection

This study identifies ZNF598 as a key factor in vaccinia virus mRNA translation by modulating ribosome quality control during infection.

Cell cycle-gated feedback control mediates desensitization to interferon stimulation

The paper investigates how type I interferon signaling in human epithelial cells processes repetitive stimulation through cell cycle-gated feedback control, revealing duration-dependent desensitization.