Calibrated ADAMTS13 inhibition prevents cardiovascular shear coagulopathy
Kenki Saito, Noriyoshi Isozumi, Yasuyuki Shiraishi, Yoshikazu Hattori, Kazuya Sakai, Tomoya Ueda, Atsushi Hamamura, Ryota Imamura, Michinori Kayashima, Kotaro Nakano, Tomoyuki Yambe, Hiroyuki Kumeta, Ryouta Shigehisa, Masashi Mori, Tomohiro Imamura, , Masanori Matsumoto
HA10, a humanized anti-ADAMTS13 antibody, preserves residual ADAMTS13 activity to prevent cardiovascular bleeding without causing thrombosis in non-human primate models.
bioRxiv · Aug 4, 2026 · PreprintBiochemistry