Anne Martel

HA10, a humanized anti-ADAMTS13 antibody, preserves residual ADAMTS13 activity to prevent cardiovascular bleeding without causing thrombosis in non-human primate models.

The paper develops a protocol combining segmental deuteration and multi-step protein ligation with SAXS and iCM-SANS to improve discrimination of conformational ensembles in multi-domain proteins.

This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.

This study characterizes the structure of the MexR-mexR repressor-operator complex using SAXS and SANS, revealing DNA bending and flexibility between binding sites.

This paper investigates glycerol's effect on myoglobin's hydration and structural transitions using scattering techniques, showing preservation of hydration shells at low concentrations and structural stabilization at higher concentrations.