A Circuit for Secretion-coupled Cellular Autonomy in Multicellular Eukaryotes
Lingxia Qiao, Saptarshi Sinha, Amer Ali Abd El‐Hafeez, I‐Chung Lo, Krishna Midde, Tony Ngo, Nicolas Aznar, Inmaculada López-Sánchez, Vijay Gupta, Marilyn G. Farquhar, Padmini Rangamani, Pradipta Ghosh
The paper identifies a GTPase circuit that enables secretion-coupled cellular autonomy in cancer cells through feedback loops and dose response alignment of growth factor sensing and secretion.
bioRxiv · Mar 18, 2021 · PreprintSystems Biology