Padmini Rangamani

This study shows that ionic strength and ionization affect membrane-tethered polymer conformation, which influences membrane curvature generation through changes in brush thickness and grafting density.

This paper develops a computational model to study how store-operated calcium entry (SOCE) affects force generation and fatigue during exercise by simulating calcium and phosphate dynamics in skeletal muscle.

This study investigates how synapsin-1 and actin form ordered nanoscale assemblies through phase separation, showing that actin scaffolds retain structural memory for condensate reformation.

This paper develops a multiscale computational model to predict skeletal muscle hypertrophy by integrating mechanical and biochemical stimuli, showing how exercise protocols affect muscle growth and shape.

The paper develops a finite-element framework to simulate mechanochemical feedback in cell shape and mechanics, revealing new insights into cell migration, neutrophil protrusion, and dendritic spine remodeling.

The paper shows that balancing actin filament nucleation and elongation is necessary to deform protein condensates into high aspect ratio structures.

This study develops an agent-based model to show how mitochondrial shape, mechanics, and fission-fusion dynamics influence axonal transport and structural integrity.

This study designs intrinsically disordered ligands that control receptor uptake via endocytosis by modulating their sequence to promote or hinder internalization.

This paper develops a mechanochemical model to predict nuclear deformation and lamina remodeling in response to substrate nanotopography and validates predictions through experiments.

This study uses a particle-based model to simulate flat clathrin lattice dynamics, showing how AP-2, clathrin binding, and diffusion affect their formation and response to EGF stimulation.

This study shows how mechanochemical feedback between confinement and actin crosslinking controls droplet shape and actin organization through dynamic relationships between bundling and deformation.

This study identifies how caveolin-1's hydrophobic residue patterning drives membrane bending through structural and computational analyses.

This paper develops a biophysical model to study how glycocalyx and membrane-cortex adhesion influence extracellular vesicle formation, identifying two instabilities and critical conditions for EV generation.

The paper shows periodic obstacles regulate membrane tension propagation in neurons, enabling localized mechanotransduction by restricting tension spread.

The paper develops a computational model to simulate how different exercise regimes affect mitochondrial fission and fusion dynamics in skeletal muscle.

The paper introduces a finite element framework for solving bulk-surface coupled PDEs in biophysics, demonstrating accuracy and applicability to moving boundary problems.

The paper develops a data-informed model of AMPK signaling using uncertainty quantification and biosensors, showing AMPK integrates inputs over time during exercise.

This paper uses Bayesian multimodel inference to improve predictive certainty in systems biology models of intracellular signaling pathways.

This study shows nanoscale membrane curvature and nuclear deformation regulate mechanotransduction by modulating YAP/TAZ nuclear localization through biophysical modeling and experiments.

The paper models synaptic spine head morphology using graph grammars to simulate actin dynamics and their effects on membrane shape.

This paper develops a biophysical model to show glycocalyx can induce membrane tube formation through critical grafting density and polymer length, facilitated by actin forces and line tension.

This paper develops a biophysical model of the glycocalyx's role in generating and sensing membrane curvature, showing how glycocalyx properties influence membrane shape and curvature sensing.

This study develops a continuum model to explain how viscoelastic interactions between the cytoskeleton and plasma membrane modulate furrow invagination velocity during Drosophila embryo cellularization.

This study shows how synaptic geometry affects NMDAR activation by altering neurotransmitter residence time and receptor opening probabilities.

This paper develops a network model of the membrane skeleton integrating myosin and membrane mechanics to show that membrane bending and spectrin/myosin turnover are critical for maintaining structural stability under mechanical stress.

The paper uses molecular dynamics simulations to show cardiolipin increases membrane spontaneous curvature and reduces bending rigidity, leading to lateral heterogeneities through curvature sensing.

The paper introduces SMART, a software tool for simulating cell signaling networks in realistic geometries, demonstrating its application to various biological systems.

This study develops a computational model showing mechanotransduction modulates the mammalian circadian clock by affecting YAP/TAZ and MRTF nuclear translocation, with implications for disease states.

The paper shows that actin-binding proteins forming liquid-like condensates can polymerize and bundle actin filaments, expanding the known set of proteins capable of this function.

The paper demonstrates that membrane curvature catalyzes actin nucleation through the condensation and activation of N-WASP by FBP17, revealing a curvature-guided mechanism for actin remodeling.