Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening
Han Zhou, Tonglian Zhou, Wenli Yu, Liping Liu, Yeonjin Ko, Kristen A Johnson, Ian A. Wilson, Peter G. Schultz, Michael J. Bollong
This paper identifies a novel small molecule scaffold targeting KLHDC2 via high throughput screening and demonstrates its utility in degrading BRD4 using PROTACs.
bioRxiv · Mar 31, 2025Biochemistry