Michael J. Bollong

This paper identifies a small molecule, M4, that inhibits influenza A and B replication by targeting the host protein STARD7, preventing vRNP nuclear export and demonstrating synergistic antiviral effects with baloxavir in mice.

This study shows that AA147, a metabolically activated proteostasis regulator, reduces TH17 cell differentiation by degrading RORgammat and IRF4, and dampens effector cytokine responses across T cell subsets.

This paper introduces DM, a detergent that reduces air-water interface artifacts in cryo-EM, improving reconstruction quality and particle stability.

This study identifies potent PDIA1 inhibitors that block NLRP3 inflammasome activity without significant cellular toxicity, offering a strategy to treat diseases involving hyperactive NLRP3.

This study identifies sCMF231, a small molecule that activates YAP by inhibiting FUBI-mediated fubylation of Annexin A2, thereby enhancing YAP transcriptional activity.

This study shows that inhibiting PGK1 with CBR-470-2 reduces NF-κB signaling by increasing methylglyoxal, which inactivates NF-κB proteins.

This paper identifies a novel small molecule scaffold targeting KLHDC2 via high throughput screening and demonstrates its utility in degrading BRD4 using PROTACs.

This study shows that pharmacologic activation of ISR kinases HRI or GCN2 prevents mitochondrial fragmentation in disease models.

This study shows methylglyoxal, a glycolytic metabolite, covalently inactivates the NLRP3 inflammasome by forming crosslinks, thereby reducing inflammation.