Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice
Nicole R. Gould, Andre F. Coello, Jennifer A. McKenzie, Tiandao Li, Katherine R. Hixon, Leyi Chen, Kristen Barwick, Tiffany S. Lee, Mariam Obaji, Bo Zhang, David M. Ornitz, Matthew J. Silva
This study shows that proliferation of early and mature osteoblasts is essential for bone fracture healing in mice, as blocking their proliferation leads to fibrous nonunion and reduced callus formation.
bioRxiv · May 27, 2025 · PreprintPhysiology