Bo Zhang

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

CiliaIO uses machine learning to quantify cilia beating dynamics in zebrafish spinal cord, revealing regional waveform differences and subtle defects in a bbs2 mutant.

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

This study identifies survival-associated CpG biomarkers in PDAC using machine learning and validates their predictive power for patient survival.

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

The paper identifies a microenvironment-driven neoantigen, C19S, in type 1 diabetes that activates persistent memory T cells through HLA-DQ8 recognition.

The paper introduces a data repository containing epigenomic data from mice exposed to various environmental toxicants, enabling research on disease susceptibility.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

ToxiTaRGET provides a multi-omics resource of molecular responses to toxicants in mice, enabling researchers to explore transcriptomic and epigenomic changes across tissues and life stages.

This study examines how early-life exposure to environmental toxicants alters TE chromatin accessibility and expression in mouse liver, revealing exposure-specific and sex-dependent effects.

The paper identifies CeA neuronal ensembles that modulate visceral pain and its affective behaviors through optogenetic manipulation and single-nucleus RNA sequencing.

This study shows that proliferation of early and mature osteoblasts is essential for bone fracture healing in mice, as blocking their proliferation leads to fibrous nonunion and reduced callus formation.

The paper introduces TSRdetector, a method to analyze differential usage of gene transcription start regions across tissues, cell types, and diseases, revealing unique transcriptional regulation patterns.

The paper shows early-life toxicant exposure reprograms epigenomic aging, altering gene expression in liver cells and disease risk in adulthood.

The paper analyzes TE-derived transcripts in 17,329 human transcriptomes across 47 adult tissues, revealing their broad expression, sex-specific regulation, and contribution to protein diversity and metabolic functions.

This study shows that endothelial Cept1 promotes post-ischemic angiogenesis and recovery, dependent on Pparα, and is elevated in diabetic peripheral arterial disease.

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

This study identifies inppl1a as a gene regulating cell expansion in zebrafish notochord, spine morphogenesis, and endochondral bone lengthening, revealing a conserved mechanism across species.

This paper shows that KDM2B suppresses Wnt signaling in neural progenitors to regulate hippocampal development and morphology.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

This study examines transcriptomic and epigenetic changes in four rat brain regions after a METH overdose, revealing region-specific responses and conserved regulatory elements linked to neurological functions.

This study uses iPSC models to show that a 15q13.3 duplication causes distinct neurodevelopmental and functional anomalies in an affected individual but not their unaffected mother, while both share increased cholinergic activity.

This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.

This paper shows that the TRPV channel OSM-9 is required for sleep-dependent olfactory memory in C. elegans, despite being expressed in sensory neurons not involved in butanone attraction.

The paper systematically maps chromatin state landscapes during mouse development by profiling histone modifications across 72 tissue-stages, identifying dynamic enhancers and transcriptional regulators.

This study identifies gene regulatory networks driving digit tip regeneration in mice, showing level-dependent differences in gene expression and tissue regrowth.

This paper identifies Geminin as a regulator of Hox gene expression in mouse limb development, showing its role in patterning limb skeletal elements through effects on Hox gene expansion and SHH signaling.

The paper introduces AIAP, an ATAC-seq analysis package that improves quality control and analysis, showing increased sensitivity in peak calling and differential analysis.

The paper introduces a web-based browser for visualizing 3D genome organization and chromatin interactions, enabling integration with other omics data to study gene regulation.