SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS
Natalie E. Farrawell, Isabella A. Lambert-Smith, Kristen Mitchell, Jessie A. McKenna, Luke McAlary, Prajwal Ciryam, Kara L. Vine, Darren N. Saunders, Justin J. Yerbury
This study shows that SOD1A4V aggregation disrupts ubiquitin homeostasis in an ALS cell model, leading to UPS dysfunction and altered mitochondrial function.
Journal of Cell Science · May 10, 2018Peer-reviewedMolecular Biology