Prajwal Ciryam

This study investigates how a GluN1 monoclonal antibody affects kinase signaling pathways in primary cortical neurons, revealing phosphoproteomic changes linked to NMDAR activation.

This study uses single-nucleus RNA sequencing to analyze CSF leukocytes after IVH, identifying distinct immune cell states and signaling networks involved in inflammation.

The paper identifies HSP70 local translation in astrocyte endfeet after cerebral ischemia using RiboTag RNA sequencing and finds it correlates with proteostasis and ubiquitination changes.

The paper identifies amino acid pairs at the ribosome's P- and A-sites that predictably and causally modulate translation-elongation rates in yeast.

The paper develops chemical kinetic methods to measure translation initiation, elongation, and codon-specific rates from ribosome profiling data, finding significant variability in codon translation rates.

This paper uses Integer Programming to accurately identify A-site locations on ribosome-protected mRNA fragments from Ribo-Seq data, improving signal-to-noise ratio by utilizing a wider range of fragment sizes.

This study shows that SOD1A4V aggregation disrupts ubiquitin homeostasis in an ALS cell model, leading to UPS dysfunction and altered mitochondrial function.