Age-Related Decline in NCKX4-Mediated Calcium Clearance Accelerates Aortic Remodeling and Drives Early Vascular Aging
Guilherme Henrique Souza Bomfim, Kesava R. Asam, Nish Patel, Kristen Rosenberg, Erna Mitaishvili, Talita Ferreira Marques Aguiar, Emmanuel Zorn, Ravichandran Ramasamy, Bradley E. Aouizerat, Rodrigo S. Lacruz
This study identifies NCKX4 as a key regulator of vascular aging, showing its decline accelerates aortic remodeling and calcification in aged mice, particularly in females.
bioRxiv · Oct 1, 2025 · PreprintCell Biology