Guilherme Henrique Souza Bomfim

This study shows that increased mitochondrial metabolism in Down syndrome iPSCs impairs neuroectoderm commitment by reducing ciliation, and this effect can be reversed by inhibiting mitochondrial calcium uptake.

This study identifies NCKX4 as a key regulator of vascular aging, showing its decline accelerates aortic remodeling and calcification in aged mice, particularly in females.