High-dimensional Ageome Representations of Biological Aging across Functional Modules
Kejun Ying, Alexander Tyshkovskiy, Qingwen Chen, Eric Latorre Crespo, Bohan Zhang, Hanna Liu, Benyamin Matei-Dediu, Jesse R. Poganik, Mahdi Moqri, Kristina Kirschne, Jessica Ann Lasky-Su, Vadim N. Gladyshev
This paper introduces Ageome, a framework to measure epigenetic age across molecular pathways in mice and humans, revealing pathway-specific aging patterns and heterogeneity in mortality prediction.
bioRxiv · Sep 17, 2024 · PreprintSystems Biology